Senin, 02 Mei 2011

[N303.Ebook] Download Ebook Samuel Beckett's Artistic Theory and Practice: Criticism, Drama, and Early Fiction, by James Acheson

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Samuel Beckett's Artistic Theory and Practice: Criticism, Drama, and Early Fiction, by James Acheson

Between 1929 and 1949 Beckett wrote a number of essays, notes and reviews. Though this early work may seem minor, there nevertheless emerges from it a consistent artistic theory concerned with the relationship between art and the limits of human knowledge. The fascinating variety of ways in which Beckett put theory into practice in his early fiction from Dream of Fair to Middling Women to The Unnamable, and in his drama from Waiting for Godot to What Where, forms the subject of this book.

  • Sales Rank: #15786292 in Books
  • Published on: 1997-02-15
  • Original language: English
  • Number of items: 1
  • Dimensions: 8.75" h x 5.75" w x 1.00" l,
  • Binding: Hardcover
  • 272 pages

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Minggu, 01 Mei 2011

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Are you separating? Do you have no idea what to expect? What does getting married really mean? The Guide to the Basics of Ontario Family Law is for everyone who: is separating or divorcing, needs to change an order or separation agreement, is involved with a children's aid society, is getting married or living "common law", or needs to understand Ontario Family Law. It explains what to do after separating and then describes each step in the Family Court. The up-to-date explanations also include: alternatives to court, mediation, arbitration, collaborative law, and negotiation. Get an overview of Ontario Family Law for both for separated couples and people getting married. Discussions include: custody/access, child support, spousal support, property division, restraining orders, marriage contracts/cohabitation agreements and other issues. There is help with children's aid society problems and adoption. The Guide has quick advice to avoid family court and tips on what to do, and not do, to get the best results possible.

  • Sales Rank: #823157 in eBooks
  • Published on: 2015-01-27
  • Released on: 2015-01-27
  • Format: Kindle eBook

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2 of 2 people found the following review helpful.
Truly excellent for anyone facing family law issues in Ontario
By BSW
This book was so helpful and gave a reality check that was much needed. Whether or not you have representation this book will enable you to understand the process and be more effective within it.

3 of 4 people found the following review helpful.
John P. Schuman in Review
By Jonathan Mitrovich
I am currently going through a divorce. It became quite a bit complex as I have little to no experience with law in general and none with Family Law. John Schuman's book is an excellent guide to the layperson who is going through or planning to go through a divorce.

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Again, it is an excellent book that even a few of my friends have borrowed and wish they would have read it prior to their divorce.

Jonathan Mitrovich

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Jumat, 29 April 2011

[V551.Ebook] Download PDF Traditions & Encounters, Volume 2 From 1500 to the Present., by Jerry Bentley, Herbert Ziegler

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Traditions & Encounters, Volume 2 From 1500 to the Present., by Jerry Bentley, Herbert Ziegler

Connect students to the stories of history. Connect students to the experience of history. Connect students to success in history. At McGraw-Hill, we have dedicated the past few years to deepening our understanding of student and instructor experience. Employing a wide array of research tools including surveys, focus groups, and ethnographic studies, we've identified areas in need of improvement to provide an opportunity for greater learning and teaching experiences. The fifth edition of "Traditions & Encounters" is a result of this. "Traditions & Encounters" also has a rich history of firsts: the first world history text to take a truly global perspective on the past; the first to emphasize connections among cultures; and, the first to combine twin themes with a seven-part framework, making the huge story of world history more manageable to both teach and learn. Now "Traditions & Encounters" becomes the first truly interactive world history program: one that marries groundbreaking adaptive diagnostics and interactivities with a captivating narrative and engaging visuals, creating a unique learning environment that propels greater student success and better course results. Instructors gain insight into students' engagement and understanding as students develop a base of knowledge and construct critical thinking skills. Chapter-opening vignettes and a lively narrative keep students turning the page while the adaptive questioning for each chapter and the personalized study plan for each individual student help students prepare for class discussions and course work. With its hallmark of twin themes, "Traditions & Encounters" continues to tell the story of the cultures and interactions that have shaped world history, while adding redesigned maps, new primary sources, and new chapter- and part-level features that strengthen connections and prompt students to analyze the events and themes in order to build a greater understanding of the past and an appreciation of history's influence on the present. Students are no longer simply reading; they are reading, interacting, and engaging in a visual, auditory, and hands-on learning experience. Give students an experience. Improve course participation and performance. Experience "Traditions & Encounters", and experience success.

  • Sales Rank: #45851 in Books
  • Published on: 2010-10-08
  • Original language: English
  • Number of items: 1
  • Dimensions: 10.80" h x .70" w x 9.50" l, 2.46 pounds
  • Binding: Paperback
  • 528 pages

About the Author
Herbert F. Ziegler is an associate professor of history at the University of Hawai'i. He has taught world history since 1980 and currently serves as director of the world history program at the University of Hawai'i. He also serves as book review editor of the Journal of World History. His interest in twentieth-century European social and political history led to the publication of Nazi Germany's New Aristocracy(1990). He is at present working on a study that explores from a global point of view the demographic trends of the past ten thousand years, along with their concomitant technological, economic, and social developments. His other current research project focuses on the application of complexity theory to a comparative study of societies and their internal dynamics.

Jerry H. Bentley was professor of history at the University of Hawai‘i and editor of the

Journal of World History. His research on the religious, moral, and political writings of

Renaissance humanists led to the publication of Humanists and Holy Writ: New Testament

Scholarship in the Renaissance (Princeton, 1983) and Politics and Culture in Renaissance

Naples (Princeton, 1987). More recently, his research was concentrated on global history

and particularly on processes of cross-cultural interaction. His book Old World Encounters:

Cross-Cultural Contacts and Exchanges in Pre-Modern Times (New York, 1993) examines

processes of cultural exchange and religious conversion before the modern era, and his pamphlet

Shapes of World History in Twentieth-Century Scholarship (Washington, D.C., 1996)

discusses the historiography of world history. His most recent publication is The Oxford

Handbook of World History (Oxford, 2011), and he served as a member of the editorial team

preparing the forthcoming Cambridge History of the World. Jerry Bentley passed away in

July 2012.

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0 of 0 people found the following review helpful.
she thought it an excellent
By pagruner
wife tutors college level history; she thought it an excellent text

6 of 7 people found the following review helpful.
CONNECT activities are just plain awesome
By Megan
As a student, I believe that the CONNECT online activities for this book are outstanding. They are much more effective than the online study aids I have utilized in other classes and with other texts. CONNECT is simply the best way to engage with history, and the exercises, quizzes, and critical missions greatly enhanced my learning experience in the classroom. They're interactive, and they're fun. I found myself remembering information and making connections that I would not have been able to draw up had I only read the text itself. A+++!

1 of 1 people found the following review helpful.
Easy to read even if you don't particularly like the ...
By B. Zom.
Easy to read even if you don't particularly like the subject. I feel like the main points were represented well and the sections were put in a way that made the book very organized and easy to find specific questions in.

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The Data Warehouse?ETL Toolkit: Practical Techniques for Extracting, Cleaning, Conforming, and Delivering Data, by Ralph  Kimball, Joe Cas

  • Cowritten by Ralph Kimball, the world's leading data warehousing authority, whose previous books have sold more than 150,000 copies
  • Delivers real-world solutions for the most time- and labor-intensive portion of data warehousing-data staging, or the extract, transform, load (ETL) process
  • Delineates best practices for extracting data from scattered sources, removing redundant and inaccurate data, transforming the remaining data into correctly formatted data structures, and then loading the end product into the data warehouse
  • Offers proven time-saving ETL techniques, comprehensive guidance on building dimensional structures, and crucial advice on ensuring data quality

  • Sales Rank: #323071 in Books
  • Published on: 2004-10-01
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.25" h x 1.10" w x 7.40" l, 1.72 pounds
  • Binding: Paperback
  • 528 pages

From the Back Cover

The single most authoritative guide on the most difficult phase of building a data warehouse

The extract, transform, and load (ETL) phase of the data warehouse development life cycle is far and away the most difficult, time-consuming, and labor-intensive phase of building a data warehouse. Done right, companies can maximize their use of data storage; if not, they can end up wasting millions of dollars storing obsolete and rarely used data. Bestselling author Ralph Kimball, along with Joe Caserta, shows you how a properly designed ETL system extracts the data from the source systems, enforces data quality and consistency standards, conforms the data so that separate sources can be used together, and finally delivers the data in a presentation-ready format.

Serving as a road map for planning, designing, building, and running the back-room of a data warehouse, this book provides complete coverage of proven, timesaving ETL techniques. Beginning with a quick overview of ETL fundamentals, it then looks at ETL data structures, both relational and dimensional. The authors show how to build useful dimensional structures, providing practical examples of techniques. Along the way you'll learn how to:

  • Plan and design your ETL system
  • Choose the appropriate architecture from the many possible options
  • Build the development/test/production suite of ETL processes
  • Build a comprehensive data cleaning subsystem
  • Tune the overall ETL process for optimum performance

About the Author

RALPH KIMBALL, PhD, founder of the Kimball Group, has been a leading visionary in the data warehousing industry since 1982 and is one of today's best-known speakers and educators. He is the author of several bestselling titles published on data warehousing, including The Data Warehouse Toolkit (Wiley).

JOE CASERTA is the founder of Caserta Concepts, LLC, a data warehousing consulting firm. He writes frequently for print and online magazines, and is an active contributor to DWList, the major online community for data warehousing professionals.

Most helpful customer reviews

2 of 2 people found the following review helpful.
A field manual for the professional
By Rufus T. Fuddpucker, Esq. III
I've been doing this for 9 years, and this is the best book I've seen on ETL procesing and its role in data warehousing. Before you start your data warehouse effort have your team read this book. Not just the ETL members...both the front/back room technicians will benefit from understanding the clear presentation of what can be in scope (dare I say, "best practice" yikes!) for ETL processing. The ideas for capturing highly valuable data quality and cleansing processes is no less helpful than the emphasis on loading the data unless it is misleading enmasse or so obviously flawed. The bias toward driving the data to the front room for presentation forces data quality issues to the surface where they must be dealt with and the loop to operational systems (or perhaps even flawed ETL transforms!) closed. Illustrates alternatives for dealing with the messy reality of suspended data, late arriving facts and dimensions. Use it as a guide for your ETL efforts. Buy this book, read it and then buy a few more for your team if you agree.

9 of 11 people found the following review helpful.
Indispensable How-To for all ETL Architects/Developers/Mgrs
By Doug Little
Ralph Kimball has rounded out his complete recipe for building fast, cost effective, robust and durable enterprise dimensional data warehouses with this immensely valuable addition to all IT & Data Warehouse professionals' bookshelves.

Without a doubt ETL has been the biggest stumbling block to deploying and maintaining well architected data warehouses that stand the test of time. Ralph draws on his years of experience and engagement with thousands of projects and crystallizes the `Best Practices' into an effective application architecture for all ETL systems regardless of what tools projects use for implementation.

In this thorough examination of the Extract, Transform and Load (ETL) process, Ralph identifies 38 critical functions that all ETL systems need to implement for success in the long haul. He thoughtfully lays out simple and practical approaches for how each of these functions can be implemented by projects with any size of budget.

For many, the paradoxical nature of ETL (seeming trivial yet replete with endlessly complex details that constantly change) has been the proverbial straw that has broken the bank for many DW projects. Continual customer pressure to grow, improve performance, and quickly deal with changing business conditions have left developers and architects grasping for more powerful and flexible approaches to ETL that meet project timelines, yet evolve and improve with age. Armed with this enlightening roadmap, many DW professionals will be far better equipped to design and build systems that meet the challenges today and tomorrow.

2 of 2 people found the following review helpful.
An essential book for a data warehouse professional
By I. Ranganathan
I have no doubt this book should be an essential guide for data warehouse professional. After reading this book, a database developer may become an expert, confident and successful in career. Project manager may find the book as essential guide in preparing detailed data warehouse project plan. The authors organized the chapters very well, packed the chapters with practical solutions.

Indy Ranga

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The Data Warehouse?ETL Toolkit: Practical Techniques for Extracting, Cleaning, Conforming, and Delivering Data, by Ralph Kimball, Joe Cas PDF

Minggu, 17 April 2011

[N122.Ebook] PDF Download Jungle Scout: A Vietnam War Story (Historical Fiction), by Tim Hoppey

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Jungle Scout: A Vietnam War Story (Historical Fiction), by Tim Hoppey

Sixteen-year-old Lam Hung was once a member of the Viet Cong. Now he's a Kit Carson Scout for U.S. Marines, ordered to steer the troops safely around explosive land mines and deadly booby traps. One mistake could mean their lives. Lam's most difficult task could be getting the platoon to trust him, a former enemy.

  • Sales Rank: #2343676 in Books
  • Brand: Brand: Stone Arch Books
  • Published on: 2008-09-01
  • Original language: English
  • Number of items: 1
  • Dimensions: 8.00" h x .20" w x 5.50" l, .20 pounds
  • Binding: Paperback
  • 56 pages
Features
  • Great product!

Review
This high interest, low vocabulary series combines a short historical fiction tale with graphic novel style illustrations. This tale has a great deal of action and appealed to the low reading group of 7th grade boys I used for field testing. Jungle Scout --Library Media Connection

About the Author
Tim Hoppey was born and raised on Long Island in New York. For more than 20 years, he has worked as a New York City firefighter in the neighborhood of East Harlem. In his spare time, Hoppey has written several children's books including Tito, The Firefighter published by Raven Tree Press. He lives with his wife Ellen, their three kids, and a 14-year-old cat named Scarlet.

Ramon Espinoza (ess-pih-NO-zah) was born in Mexico in 1978. Espinoza grew up reading comics, and at age 20 enrolled in a fine art school. Since graduating, he has worked as an animator, colorist, and storyboard artist for advertisments and short films. He has a published comic strip in Switch magazine, as well as short stories for Max and FHM magazines. Espinoza currently lives in Mexico, with his wife Caro and his dog Bondi.

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Rabu, 13 April 2011

[O160.Ebook] Ebook Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure, by Travis Christoffers

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Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure, by Travis Christoffers

A masterful synchronization of history and cutting-edge science shines new light on humanities darkest diagnosis. In the wake of the Cancer Genome Atlas project's failure to provide a legible roadmap to a cure for cancer, science writer Travis Christofferson illuminates a promising blend of old and new perspectives on the disease. Tripping over the Truth follows the story of cancers proposed metabolic origin from the vaunted halls of the German scientific golden age, to modern laboratories around the world. The reader is taken on a journey through time and science that results in an unlikely connecting of the dots with profound therapeutic implications. Transporting us on a rich narrative of humanities struggle to understand the cellular events that conspire to form malignancy, it reads like a detective novel, full of twists and cover-ups, blind-alleys and striking moments of discovery by men and women with uncommon vision, grit and fortitude. Ultimately we arrive at a conclusion that challenges everything we thought we knew about the disease, suggesting the reason for the failed war against cancer stems from a flawed paradigm that categorizes cancer as an exclusively genetic disease.��For anyone affected by this terrifying disease, and the physicians who struggle to treat it, Tripping�Over the Truth�provides a fresh and hopeful perspective. It explores the new and exciting non-toxic therapies born from the emerging metabolic theory of cancer. Therapies that may one day prove to be a turning point in the struggle against our ancient enemy. We are shown how the metabolic theory redraws the battle-map, directing researchers to approach cancer treatment from a different angle, framing it more like a gentle rehabilitation rather than all-out combat. In a sharp departure from the current "targeted" revolution occurring in cancer pharmaceuticals, the metabolic therapies highlighted have one striking feature that sets them apart -the potential to treat all types of cancer because they exploit the one weakness that is common to every cancer cell: dysfunctional metabolism.

  • Sales Rank: #3887 in Books
  • Published on: 2014-10-08
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.00" h x .74" w x 6.00" l, .0 pounds
  • Binding: Paperback
  • 296 pages

Review
"An iconoclastic information-rich narrative that boldly challenges our current understanding and treatment of cancer." - Joseph C. Maroon, M.D., author of�The Longevity Factor
"This is a great scientific mystery book...This book is for everyone, but should be read by all physicians that treat cancer. I congratulate the author for a marvelous job and highly recommend this book." - Robert L. Elliott, M.D., Ph.D.

"I couldn't put it down and finished it in two days." - George Yu, M.D.

"While acknowledging that the metabolic theory of cancer has been rejected by the scientific establishment for most of its century of existence, the book presents a convincing argument for taking a new look at the work of scientific renegades whose work suggests that a combination of diet modifications and drugs may be a far more effective treatment than genetic treatment, and far less expensive....�A well-written account of a nonstandard but plausible theory of oncology." -- KIRKUS REVIEWS

About the Author
Travis Christofferson lives in the Black Hills of South Dakota with his wonderful wife and two charming children.

Most helpful customer reviews

132 of 136 people found the following review helpful.
Very readablel book on the history, theory, and potential of the metabolic theory of cancer.
By Edward Miller
This is a must read for those interested in cancer.

The author uses a historical framework to explain the science, and makes a strong case for cancer as a metabolic disease (as contrasted to a genetic one). More importantly, cures are to come from studies of metabolism, rather than from narrowly targeted treatments aimed as particular mutations.

The treatment is historical, telling the story through the great researchers and their findings, using their stories to explain the science. This makes the book very readable. Telling these stories is not necessary to understanding the science, but it may be necessary to understanding why, and when it was accepted.

After running through various historical figures, such as Warburg (who got his Nobel prize for demonstrating the metabolic abnormality of cancer), the story moves to various interesting modern figures.

By page 93, he reaches the research in Pedersen's lab at John Hopkins University, and the story of the bright Korean biochemist, Young He Ko. She discovers that a simple chemical, 3-bromopyruvate, kills cancer cells better and quicker than most chemotherapy drugs. She achieves the almost unprecedented feat of curing cancers in all of 19 rats, who remain free of their original cancers to the end of their natural life.

One would expect to learn how she got a professorship, fame, and lots of research money. Instead, the academic politics at John Hopkins results in her being terminated, and a law suit, leaving the breakthrough unexploited. (Some believe that this will provide the plot for a movie, and speculate as to which actress should play Dr. Ko). For now, it just makes part of the book read like a novel.

There is drama (starting on p. 109) when the father of a teenager near death from liver cancer hears of the new drug, and obtains approval for it to be administered in Germany (approved only because it was his only hope of evading his impending death). The unemployed biochemist travels there, and waits nervously while the first human receives it. He was being kept alive by tube feeding. There are no serious side effects, and he asks to eat. The outcome is that instead of not surviving to his 17th birthday as the doctor's predicted, he recovers enough to go to John Hopkins Medical school to lecture, reaches his 18th birthday (a party which the still unemployed Dr. Ko attends). Alas, he eventually dies from an unrelated pneumonia, but the drug had achieved a "miraculous" cure. Heart breaking drama here.

The story then moves on to the cutting edge research on the genetics of cancer, and how when the genomes of various tumors were sequenced, there was found there was no pattern to the mutations, creating an embarrassment for those whose careers had been based on the genetic theory of cancer.
Naturally those who had dedicated their career to cancer as a genetic disease were disappointed, and elaborate new theories, but several of the leaders have shifted their focus to metabolism. Although it is easy to say the hundreds of millions spend on genetic research was wasted, it was something that should have been done, and it appears we now know approaches that do not work.

As a subplot (p152) is the story of James Watson (whose Nobel prize was for discovering the genetic code) and his shift from emphasis on genetics (which naturally served his self interest), to efforts to get the Ko formulation, and him expressing support for the metabolic theory (when famous geneticists abandon the genetic theory, it is more convincing).

The story moves on to Dr. Seyfried (p. 167) and how he drifts into cancer research on discovering that starving mice slowed tumor growth, and a drug that seemed effective against cancer actually seemed to work by stopping the mice from eating as much (the control mice not given the drug died much quicker, but control mice restricted to eating only as much as the treated mice chose to eat, did just as well).

This resulted in the publication of a path breaking book, The Metabolic Theory of Cancer. " While this is a very good book, and a must read for professional cancer researchers, the biochemistry is tough for non-professionals. For laymen, one can get an understanding from "Tripping over the Truth" with much less work.

Even the professional may find that the historical narrative of this book makes it easier to understand Seyfried's book (Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer), with much less work, and without being lost in the details. Such reader's may wish to skip the first two parts, which provide historical and scientific background).

Christofferson's book is cheaper, slightly more up to date (in a field that is moving fast, partially due to Seyfried's recent book), and more fun to read. After reading Christoffer's account of how Seyfried came to write his book, and what he found, the professionals will be motivated to read the more technical book written by the great scientist himself.

Dr. Seyfried explores ketones as the explanation for why calorie restriction works, and shows that a ketogenic diet can be effective (at least in mice). The story moves on to the history ketogenic diets, and to a Florida researcher, D'gostino (p.211), who gets good results in mice from such a diet, especially when combined with hyperbaric oxygen therapy.

Small scale human tests of ketogenic diets for brain cancers begin (p. 196) and produce encouraging results.

Since many reading this review will be those suffering from cancer, what are the conclusions for such patients The first is the high potential of 3-bromopyruvate. Patients should not rush out and try to get this and treat themselves. If incorrectly formulated, it could be fatal. However, they should keep their eyes open for trials (which are overdue, but virtually certain to come). Those with advance, metastatic cancer should try to be included, even if this requires traveling overseas, and paying their own expenses.

The preliminary evidence is that a ketogenic diet is beneficial, and the book includes an appendix on "Putting Metabolic Therapy to Work". If I was dying from cancer, I would certainly try this.

What are the weak points in the book?

One is that it lacks an index (so those interested in a particular topic can find it). Even the chapter headings and table of contents are non-informative. This is why I mentioned page numbers above.

While it has a list of sources in the back, it is not as well documented as a researcher would want. Fortunately, more can be found in Seyfried's book.

It is clear from the sources he gives, that much of his information derives from traveling around the country interviewing the researchers themselves. This permits him to provide the background that makes the book so readable (even novel like). A benefit of these interviews is that he sometimes mentions results that have not yet been written up and published. This could be valuable to researchers and funders wanting to know what is going on in a fast moving field.

Those interested in the history and politics of science will enjoy the stories of the researchers, and how what should have been obvious leads and inconsistencies were not followed up on. It also becomes clear how problems of funding, human egos and ambitions, and desire not to confess to having wasting time on exploring a blind alley (even though this may keep others from wasting time by going down the same blind alley) has impeded research. Possible cures that are hard to make money from such as 3-bromopyruvate (a known chemical that cannot be patented) and nutritional approaches are not as promptly followed up on as those that can result in a highly profitable drug of marginal use (and he points just how marginal many of the hyped drugs are).

Those in funding positions (government, foundations, and those with money to donate) would benefit from reading this book and thinking about the implications. Drug companies naturally would like funding decisions that lead to new drugs them to patent and market, and research that shows the utility of their products (and lobby for such). However, much higher returns should result from research private firms are unlikely to pursue, research on unpatentable molecules like 3-bromopyruvate, and nutritional therapies.

109 of 112 people found the following review helpful.
A story about the struggle for discovery that most people never will see! The women researchers need to read it!
By george yu md
A review of Tripping On The Truth by Travis Christoferson

An engaging book to read for layman as well as professionals!

For the layman, it is readable, fun and packed with information that applies cancers forefronts and your health in general. For the professionals, it will give you a clearer understanding of what is going on behind and beyond the day to day news on cancer research and treatments.

I could not put it down and finished it in 2 days-it reads like a suspense mystery yet has the full impact of what is really going on with the research and problematic issues both in the basic science and clinical practice of cancer biology and future clinical management. Sandwiched within these topics, the reader will have a glimpse of the intrigue, politics, and the fierce competition that most of us never see or understand in the struggles of big research, big players, and huge financial implications in the industry of cancer health.

As a doctor and surgeon, I kept the discipline of examining with my surgical pathologist every cancer operation I performed, hoping to uncover its behavior. What doctors see on H & E stains for microscopic slides are the cancer with strange nucleus containing the DNA and its cell division, mitosis. But if microscopic examination could have shown the strange and abnormal mitochondria energy packets in these cancer cells (seen only with the costly electron microscopy) perhaps we would have, long time ago, embraced the issues of cancer energy abnormalities and not have chased the nuclear DNA as much as we have.

In parts of the book on Peter Pedersen and Young Ko and the discovery of Hexokinase 2 and ultimately 3 Bromo pyruvate, the politics and intrigue reminds me of the heavily debated conflicts that we saw with Rosaland Franklin and James Watson and Francis Crick on the discovery of the structure of DNA (Rosalind Franklin, The Dark Lady of DNA by Brenda Maddox) and Candance Pert and Solomon Synder (Molecules of Emotion by Candice Pert) on the opiate receptor discovery. Both discoveries involved severe competition with a touch of gender discrimination. Could this happen with the discovery of 3 Bromo pyruvate anticancer molecule? Young Ko and Peter Pedersen have not been dealt unfairly or unjustly and this book brings out all these ugly issues and conflicts often seen in high power science as in all other human endeavors.

TCGA the cancer genome atlas project and the obvious pathway
revealed by the PET scans showing another cancer feature.

With failures of the billion dollar chase to uncover the gene mutations of all types of cancers (TCGA), most of us were frustrated and deflated by the futility of the gene mapping approach for future treatment options. So why not look at something obviously staring at us clinicians!

We, as clinical surgeons and oncologists deal with diagnostics daily on patients with localized and advanced cancers managements, we use CAT and PET scans to see the extent of the cancer spread. But rarely did we question how this PET scan came to being. It turns out that what we practicing doctors use to see cancer function is nothing more than the uptake of FDG sugar in the cell and in the mitochondrial hexokinase 2 deformity (almost universal in all cancers with only a few exceptions). After all the PET scan is simply the cancer’s need for sugars and fuel by glycolysis (fermentation) and in the hexokinase 2 in cancer mitochondria discovered by Peter Pedersen.

The review by Ralph Moss in Advances in Cancer Treatment October 2012, a patient cancer advocacy, presented a beautifully written summary and critique of the whole new approach to cancer but actually an old concept with a new trust upon the discovery of the uses of molecules such as Dichloroacetate and 3 Bromopyruvate. More will come to notice in the next five years.

What is also tied to the energy abnormalities of cancers in general is the long history of the study of Caloric Restriction consistently decreasing the growth of cancers seen in animal studies. On a human level, there groups of people and institutions claiming good successes and practice with low calorie high nutrition (1800 calories per day) diets both for cooked and raw foods such as The Caloric Restriction Society, Optimal Health, Hippocrates Institute, Ann Wigmore institute, and Kushi Macrobiotic Institutes etc. In essence most of these organizations have probably been practicing a form of energy deprivation of cancer cells for over 50 years and still going strong, but not accepted by the medical community accept in study scenarios at the National Cancer Institute.

I recommend two books if the readers are really interested in the science behind the popular paradigm shift on cancer research and future cancer patient care.
Tom Seyfried’s book, Cancer as a Metabolic Disease, is a well written narrative of studies done in the last 50 years point to one simple concept. The analogy of the fly fisherman is what we call cast to the upstream problem to have a better chance of landing a fish hook up instead of downstream when the fish already have passed the fly. The metabolic abnormality of these cancers could be the upstream effect which then leads to nuclear gene instability and mutations- not DNA mutations first but the mitochondrial energy packets as the first abnormality.

The second book by Jiri Neuzil, Shazib Pervaiz and Simone Fulda, Mitochondria: The Anti-cancer Target for the Third Millenium is an international consortium of research on targeting energetic metabolism of cancer biology. It is heavier reading than the Seyfried book

161 of 169 people found the following review helpful.
READ THIS BOOK!
By Tuit Nutrition
Cancer: It's a terrifying diagnosis, often eventually resulting in one of two possibilities: either a prognosis that amounts to a death sentence, or, if more optimistic, a likelihood of "beating it," with the prospect of then spending the rest of one's life with back-of-the-mind worry that it will come back someday. Why have we made so little progress in treating this illness? Why, over four decades after President Nixon declared "war on cancer," do millions of people still experience the ravages of this disease and its toxic conventional treatments? When we set out to build an atomic bomb, we had the Manhattan Project, and we accomplished it. When we decided we wanted to land a man on the moon, we threw money at the idea, and we accomplished that, too. So why, after forty years, billions of dollars, and thousands of biochemists and researchers devoting their careers to solving the mysteries of cancer, have we made shamefully few inroads?

Is there a chance we've approached things from the incorrect angle? Is there a chance that we've mischaracterized the etiology of cancer, and because of this, our therapies, medications, and prevention strategies are misguided and ineffectual? What if, all these years, cancer has had most of us fooled, and all but a few brave and persistent scientists have been so distracted by the *effects* of cancer that we've inadvertently ignored the underlying cause?

These are the questions Travis Christofferson explores in Tripping Over the Truth. In a book that covers cancer from its earliest recognition centuries ago, to therapies and drug trials that are ongoing now, Christofferson makes a stunning case suggesting that the reason our go-to treatments of surgery, radiation, and chemo ("slash, burn, and poison") so often fail to restore health and save lives is that they're targeting the wrong thing. You can't provide an effective solution if you don't know what the problem is. And a growing number of researchers believe we've been throwing solutions around in what amounts to either a guessing game or an ultra-high-stakes version of "whack-a-mole," where as soon as one problem goes away, another pops up somewhere else. But if we could find the root cause--the fundamental underlying problem in cancer--then we can attack it head-on and get rid of it once and for all.

Christofferson details the differences between two competing theories of cancer etiology, with well-researched timelines covering the political, economic, social, and academic forces behind both. The one more widely-held right now is the "somatic mutation theory" (SMT). It posits that cancer is caused by mutations to DNA. Carcinogenic substances cause errors in DNA replication, and this leads to cells that misbehave--they gobble up fuel, they create their own blood supplies (angiogenesis), they poison nearby cells, and they divide and multiply like crazy. They never die, like normal cells are programmed to do (apoptosis), and eventually, they spread from their site of origin and take root somewhere else in the body (metastasis). This theory makes sense, because cancerous cells do have mutated DNA.

However, the competing theory--the metabolic theory--holds that mutated DNA is merely an *effect* of cancer, not the cause. This theory suggests that cancer is the result of an energy problem inside cells--specifically, the mitochondria have lost the ability to adequately perform "cellular respiration" and oxidative phosphorylation--making ATP. In other words, it's an energy generation problem. When mitochondria lose the ability to "respire" and create energy, they revert to fermentation instead, a primitive, highly inefficient survival mechanism that requires enormous amounts of glucose to power a cell. One of the products of fermentation is lactate (lactic acid), which accounts for the acidosis so common in cancer patients, and this is why alkalinizing therapies fail: people don't get cancer because their blood is acidic; their blood becomes acidic because the cancer cells generate so much lactate. It's also why advanced cancer patients waste away (cachexia): the cancer cells "steal" glucose from the rest of the body, growing and spreading, while the rest of the body starves and shrinks.

Think about it: When you haven't slept in a while, you haven't been eating right, and you're under stress, you make mistakes, right? You're tired, and you get sloppy and clumsy. Cells work the same way: when the mitochondria are damaged and can no longer produce energy effectively, cells get sloppy. They make errors in DNA replication--so we can see the mutations here as consequences, not causes.

The real crux of the metabolic theory is the glucose issue. Researchers have known for years that cancer cells are "sugar junkies." They thrive on glucose, and because their mitochondria are either inadequate in number or are dysfunctional, they fail to effectively metabolize fuel sources that healthy cells can use just fine: fatty acids and ketones. The mitochondria are so broken that even in the presence of oxygen, cancer cells must ferment glucose--the "Warburg effect," and an unmistakable hallmark of most cancers.

Cancer cells' "Achilles' heel" is their reliance on glucose for survival. If the metabolic theory holds true, then targeting cancer cells not at the level of DNA, but at the level of metabolism, might hold the key to developing successful therapies. We are still in the early stages of exploring this in the clinical setting (largely using ketogenic diets and hyperbaric oxygen), but Christofferson makes a powerful case for why these non-toxic therapies stand a much better chance of hitting cancer where it hurts than the chemo and radiation, which often take people's lives faster and more brutally than the cancer itself would have, if left untreated. (Moreover, unlike chemo & radiation, metabolic therapies would *spare* healthy tissue -- and in the case of a ketogenic diet, possibly even *strengthen* it. At the very least, metabolic therapies prime the body to better tolerate the harsh effects of conventional treatment.)

Christofferson details the origins of the SMT, and then systematically dismantles its every tenet. For each weakness in the SMT, the metabolic theory has a fascinating strength. Pitted head-to-head, the metabolic theory fits the evidence much more logically and scientifically. It's unfortunate that so much time, money, and research effort have been expended to hit all those "whack-a-moles" one by one with the plastic hammer, when the answer all along might have been simply to unplug the machine and cut off its power supply altogether.

Borrowing from the work of many scientists, Christofferson has written a book appropriate for medical professionals as well as laypeople interested in this topic. The more scientifically minded might go on to tackle Dr. Thomas Seyfried's book, Cancer as a Metabolic Disease. But for those who just want to begin exploring these concepts, Tripping Over the Truth is a great introduction to the beauty and elegance of the metabolic origins theory, without the intimidating biochemistry and physiology. I applaud the author for writing a book about a complex scientific subject that reads like a novel. The prose is highly readable, and the descriptions of the major players provide a good sense of who they are and what motivates them.

If the metabolic theory of cancer proves true, we will have these courageous scientists to thank, for persisting in their beliefs and holding fast to the notion that cancer is not an unsolvable riddle, but rather a biologically and evolutionarily conditioned response to an energy crisis due to mitochondrial insufficiency and dysfunction. And the most beautiful part of all: there are perfectly logical, *non-toxic* therapeutic avenues that can drive a stake right through cancer's heart.

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[Y526.Ebook] Free PDF Employment Law for Business Students, by Janice Nairns

Free PDF Employment Law for Business Students, by Janice Nairns

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Employment Law for Business Students, by Janice Nairns

Employment Law for Business Students, by Janice Nairns



Employment Law for Business Students, by Janice Nairns

Free PDF Employment Law for Business Students, by Janice Nairns

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Employment Law for Business Students, by Janice Nairns

Employment Law for Business Students is the ideal companion to support non-law students in their studies. Written with the needs of business students in mind, the book combines clear and straightforward explanations of all aspects of employment law with a strong practical focus ensuring students gain a full understanding of how employment law operates in the workplace.

  • Sales Rank: #3781123 in eBooks
  • Published on: 2011-09-21
  • Released on: 2011-09-21
  • Format: Kindle eBook

About the Author
About the author: Janice Nairns LLB (Hons), LLM, PGCE (HE), Barrister was formerly Senior Lecturer in Law at the University of Teeside with over 10 years' experience in the teaching of employment law to both business and LLB students. She has a particular interest in discrimination law issues.

Most helpful customer reviews

0 of 0 people found the following review helpful.
This is great author.
By Sammy
Giving this a 4 star because haven't read it yet but I used the previous edition while I was in uni and I made a 1st in Employment Law. My tutor actually used this for the curriculum. This is great author.

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